interleukin-8 but not interleukin-6 variant may affect susceptibility to brucellosis
نویسندگان
چکیده
background: increased levels of interleukin-8 (il-8) and interleukin-6 (il-6) in acute human brucellosis have been reported. previous studies have shown that the production and level of il-6 and il-8 cytokines are associated with the polymorphism of the encoding genes. objective: to investigate the probable association between il-6 (-174 c/g) and il-8 (-251 a/t) gene polymorphisms and susceptibility/resistance to brucellosis. methods: the patient group included 196 patients suffering from brucella infection and the control group consisted of 82 healthy animal husbandmen from the same geographical area. il-8 (-251 a/c) and il-6 (-174 c/g) gene polymorphisms were analyzed by pcr-rflp and allele specific pcr (as-pcr) respectively. results: the frequency of -251 il-8 aa genotype was significantly lower in the controls compared with that of the patients (p=0.0051), while the frequencies of other genotypes (at and tt) and alleles (a and t) were not significantly different among the participants. no association was found between il-6 (-174 c/g) polymorphism and brucellosis. conclusion: this study indicates that the il-8 -251 aa genotype may be considered as a genetic susceptibility factor for brucellosis.
منابع مشابه
Interleukin-8 but Not Interleukin-6 Variant May Affect Susceptibility to Brucellosis
Background: Increased levels of interleukin-8 (IL-8) and interleukin-6 (IL-6) in acute human brucellosis have been reported. Previous studies have shown that the production and level of IL-6 and IL-8 cytokines are associated with the polymorphism of the encoding genes. Objective: To investigate the probable association between IL-6 (-174 C/G) and IL-8 (-251 A/T) gene polymorphisms and susceptib...
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عنوان ژورنال:
iranian journal of immunologyجلد ۱۰، شماره ۳، صفحات ۱۵۸-۱۶۶
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